Freie Mitteilungen 3
4. November 2022, 11:00 - 12:00, Gartensaal 2


Sit-to-stand muscle power is related to functional performance at baseline and after supervised exercise training in patients with lower extremity peripheral artery disease
S. Lanzi, A. Pousaz, L. Calanca, L. Mazzolai, Presenter: S. Lanzi (Lausanne)

Patients with peripheral artery disease (PAD) have decreased muscle power contributing to functional limitations. The sit-to-stand (STS) is a validated test to assess muscle power in older individuals; however, it has never been investigated in patients with PAD. We evaluated the relationship between STS muscle power and common disease-related outcomes in patients with PAD at baseline and following supervised exercise training (SET).
This observational study investigated patients with Fontaine stage II PAD. Before and after SET, maximal treadmill walking distance (MWD), functional performance tests (six-min walk, STS, stair climbing, habitual gait speed), and quality of life (SF-36 questionnaire) were assessed. Relative ( STS muscle power was calculated using a validated equation. Simple and multiple regressions models were used.
Ninety-five patients with PAD were included (63.1±12.1 years, 67% male). Relative STS muscle power (before: 2.7 (95%CI 2.5–2.9); after: 3.3 (95%CI 3.1–3.6)), MWD (before: 367.0 m (95%IC 302.4–431.5); after: 598.4 m (95%IC 515.6–681.3)), six-min walking distance (before: 418.3 m (95%IC 399.4–437.2); after: 468.8 m (95%IC 452.7–484.9)), stair climbing performance (before: 6.8 s (95%IC 6.2–7.4); after: 5.3 s (95%IC 4.9–5.7)), and habitual gait speed (before: 1.10 m.s-1 (95%IC 1.05–1.14); after: 1.18 m.s-1 (95%IC 1.14–1.22)) significantly increased following SET (P≤.001). Similarly, physical (before: 31.4 (95%IC 29.4–33.3); after: 35.8 (95%IC 33.9–37.7)) and mental (before: 39.5 (95%IC 37.0–42.0); after: 43.1 (95%IC 40.9–45.4)) component summaries of the SF-36 significantly improved (P≤.001). Greater relative STS muscle power at baseline was significantly related to greater baseline treadmill (β≤.380; P≤.002) and functional (β≤.597; P≤.001) performance, and quality of life (β≤.291; P≤.050). Larger increases in relative STS muscle power following SET were associated with greater improvements in functional performance only (β≤.419; P≤.009). In contrast, there were no significant relationships between changes in relative STS muscle power and changes in treadmill performance and quality of life following SET.
STS test may provide a practical and easy clinical tool to monitor overall functional status before and after exercise interventions in patients with symptomatic PAD.
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