47 - Young Investigator Meeting
Young Investigator Meeting
4. November 2022, 13:00 - 14:00, Gartensaal 2


Mortality rate related to peripheral artery disease: a retrospective analysis of epidemiological data (years 2008 - 2019)
D. Voci1, U. Fedeli2, L. Valerio3, E. Schievano2, M. Righini4, N. Kucher1, D. Spirk5, S. Barco1, Presenter: D. Voci1 (1Zurich, 2Padua, 3Mainz, 4Geneva, 5Bern)

Peripheral artery disease (PAD) is one of the most prevalent cardiovascular diseases with more than 230 million people being affected worldwide. As highlighted by the recent guidelines of the European Society of Cardiology, data on the epidemiology of PAD is urgently needed.
We accessed the vital registration data of the Veneto region (Northern Italy, approximately five millions inhabitants) covering the period 2008-2019. We computed annual age-standardized rates for PAD reported as the underlying cause of death (UCOD) or as one of multiple causes of death (MCOD). Age-adjusted odds ratios (OR) served to study the association between PAD and cardiovascular comorbidities.
The age-standardized mortality rate for PAD as MCOD slightly declined from 20.4 to 18.3 in men and from 10.4 to 10.0 deaths per 100,000 population-years in women during the study period. The age-standardized PAD-related mortality rate declined from 4.7 to 4.6 in men and increased from 3.2 to 3.6 deaths per 100,000 population in women. (Figure 1) These trends were not statistically significant. PAD contributed to 1.6% of all deaths recorded in the region. Ischemic heart disease, diabetes mellitus, and neoplasms were the most prevalent UCOD among PAD patients. (Table 1) PAD was strongly associated with diabetes mellitus (OR 3.79, 95%CI 3.55-4.06) and chronic kidney diseases (OR 2.73, 95%CI 2.51-2.97) in men and with atrial fibrillation (OR 2.26, 95%CI 2.10-2.44) in women. (Table 2)
PAD remains a substantial cause of death in the general population of this high-income region of Western Europe with marked sex-specific differences.
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